IIH: idiopathic intracranial hypertension
David Kinshuck, from lectures
- ICP = intracranial pressure (pressure in the brain).
- IIH = idiopathic intracranial hypertension (the name of the condition)
- CSF = cerebrospinal fluid (the fluid aound the brain)
- papilloedema = swelling of the brain due its the high pressure
IIH occurs 90% in women, and 95% are <50y age, and is linked to obesity. Patients present with headaches and papilloedema (a type of swollen optic nerve). There may be blurred vision, or double vision. There may be visual obscurations (the sight reduces for a few seconds and returns by itself) and pulsatile tinnitis (noises in the ear linked to heart beating). Brain scans are needed and the intracranial pressure (measured by a lumbar puncture) is raised. The scan will need to exclude other conditions. IIH was formally termed benign intracranial hypertension. Eye news 17:
BMI many obese IIH women socially deprived, use accident and emergency departments, not their gp. Bariatric surgery is needed often ig BMI > 35 (if the community weight loss program was not effective). Baritric surgery is generally more effective that the community weight loss program .
The IIH headache is related to cutaneous allodynia.
Treating obstructive sleep apnoea if present will help significantly.
- Symptoms and signs of raised intracranial pressure including papilloedema.
- Elevated CSF pressure >25 (left lateral decubitus position). This is raised intracranial pressure (ICP). Maximum healthy ICP are 25 adult, 28 children.
- Normal csf protein etc.
- No venous sinus thrombosis on CT/MRI angiography.
- No secondary causes such as hydrocephalus, space occupying lesion, etc.
- No cns signs except cranial nerve palsy.
- there are many studies indicating that losing weight helps in the condition. 2017
- Other treatments merely help headaches or lower the pressure temporally (acetazolamide) or more long term such as CSF shunting operations
- bariatric surgery may turn out to be the best treatment for the condition
- Exenatide (an anti-diabetic drug) may be very helpful treating idiopathic intracranial hypertension. This is a glucagon-like peptide-1 (GLP-1) receptor agonist 2017.
- The headaches after the papilloedema may still be unpleasant, and are due to a combination of raised intracranial pressure, medication overuse, stress or migraine.
- An exacerbation of headache may respond to ibuprofen (but need to check for papilloedema).
- Topiramate 2007
New research: a sequence of events
- New studies identify that there may be anatomical abnormalities causing stenosis of the dural sinus (congenital). But in addtion some of this stenosis may be from brain swelling linked to a certain type of biochemistry, and it is the combination that causes the condition. The biochemical problem is linked to a congenital difference in the patients from normal and the combination with obesity.
- Thus IIH is due to a combination of obesity, which due to genetic biochemical differences, causes extra brain swelling around the dural sinuses in the brain, and the narrow dural sinuses, which then obstructs the flow of CSF, and this ncreases the intracranial pressure.
- 92% headache
- 72% obscuration
- 60% noises/tinnitus, pulsatile
- diagnosis of exclusion
- Headache commonest sign, but 10% no headache
- check drugs ..vitamin a, isotretinoin
- if IIH is suspected, a lumbar puncture is needed
- a lumbar puncture is needed to exclude other diseases : pressure/protein/cytology/glucose ned examining
- MRVenography to exclude sinus thrombosis
- full at onset, later field loss
- large blind spot, generalised constriction, reversible
- arcuate/altitudinal, (infarcts, not reversible)
- All optic nerve swelling needs investigation
- IIH affects children, more girls, but is commoner after puberty
- if may follow recent weight gain in older children
- Younger children half overweight, older most overweight,
- Downs, turners, sickle cell, anaemia, transretinoic acid, growth hormone, thyroxine etc all may contribute
- may need sedation for lp, deep sedation, have slightly higher opening pressure.
- VIn palsy and papilloedema children.
Treat papilloedema itself
- azetazolamide (diamox) helps JAMA 14 JNO 16 JNO 16
- older patient 4 g day maximum
- Frusemide acute to buy time, steroids, surgery
- Shunt, for fulminant, progressing, or severe headache
- if the IIH is severe with a really swollen disc a shunt is often needed
Treat underlying problem, obesity
- treating obesity is the main treatment
- Bariatric Surgery JNO 16... Bariatric surgery helps..20. Minutes for gastric band
- Weight loss helps, androgen pathway improves 5 alpha reductse...this is linked to papilloedema.
- Psychological treatment is the main treatment to help patients lose weight, as they put weight on tinnitus and headaches and papilloedema returned.
- 11beta hsd1 elevated in obesity in Choroidal plexus...this level reduces with weight loss and is related to improvements in papilloedema
- Glp1 glucagon like peptide 1, which reduces appetite, liraglutide, may be helpful 2017
- retest fields if stable JNO 16
- Monitor Goldman field
- Humphrey reasonable
- Oct elevation easiet NFL Longitudinal disc volume Oct Phoms, sign of ICP Segmentation essential
- How do you persuade patients to lose weight, weight loss is the treatment, and can discharge, work out which patients can lose weight and which can't.
- Patients don't like term obesity, overweight not the first visit, discuss later in outpatients
- Headache is the main determinant of quality of life
- increasing in incidence due to increasing obesity
- empty sella (effect of high ICP)
- disc haemorrhages increase risk BJO 17
- stop minocycline (can cause IIH)
- 16y girl, 6 week headache,good vision, lp 25
- Spontaneous venous pulsation present os not papilloedema
- drusen b scan optic nerve and needed to treat tension headache
- Elevated nerves and field defect..hyperaemic disc swollen= iih
- 24 h lp monitoring, pressure
- Swollen discs ha, icp++++
MRI venography normal
using Vitamin a supplements
"The incidence of IIH in Scotland is at least 2.65/100,000. This figure rises to 37.9/100,000 in obese females aged 15–44." Eye 19